Tm Analysis System

Tm analysis systems can accelerate the development process and improve the quality of oligonucleotide therapeutics. Control by LabSolutionsTM software enables compliance with ER/ES-related regulatory requirements and improves the efficiency of analyzing the thermal stability (Tm analysis) of nucleic acids.

What is a Tm Analysis System?

Tm analysis serves an important role in checking the thermal stability and sequence of nucleic acids. In Tm analysis, heat is applied to the nucleic acids in double-strands. Then, the change in absorbance (melting curve) that occurs as the temperature increases and the strands dissociate into single strands is measured. The melting temperature (Tm value) is determined as the temperature where the mole fractions of single and double strands are equal.

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How to Measure Melting Temperature using the Shimadzu TM Analysis System

Shimadzu’s new Tm Analysis system comprises of the UV-Vis spectrometer, the TMSPC8i temperature-controlled cell holder, and the LabSolutions UV-Vis Tm Analysis software. Determination of melting temperature for your biomolecules can be achieved with great flexibility and efficiency. Annealing, blank correction, temperature reverse, spectrum acquisition of samples can be finished within the Tm Analysis software. The new sealing method on the TMSPC-8i hardware almost get rid of sample evaporation near boiling temperature. Optional LabSolutions DB/CS software enables compliance with ER/ES-related regulatory requirements. Overall, this is an amazing tool for your oligonucleotide/peptide therapeutic research.

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