Metabolomics
Triple Quadrupole LC-MS/MS Comparison
Triple quadrupole mass spectrometry (TQMS) is a versatile tool for quantitative analysis. Experience the excellent performance and robustness of Shimadzu’s LCMS-TQ instruments, which offer a choice of speed, sensitivity and resolution to meet the demands of high-throughput routine analysis and/or more specialized applications.
Compare Shimadzu’s triple quadrupole LC-MS/MS systems below.
Triple Quadrupole LC-MS/MS Comparison
LCMS-8060RX | LCMS-8050RX | LCMS-8045RX | ||
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Features | The LCMS-8060RX builds on the exceptional sensitivity and UF capabilities of the LCMS-8060NX and adds even more robustness without compromising sensitivity. | Engineered to deliver excellent sensitivity the LCMS-8050RX further extends the performance of the LCMS-8050 to meet the ever-changing needs of any LC-MS/MS laboratory. | Designed for rugged, routine LC-MS/MS analysis with the optimal balance of cost, sensitivity and performance now enhanced with greater robustness and easier to use. | |
Sensitivity (S/N) | ![]() |
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Scan Speed | ![]() |
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Ionization Unit Compatibility | ESI | |||
APCI |
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DUIS*1) |
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Heated-ESI |
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Heated-ESI with IonFocus |
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Micro-ESI |
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Probe-ESI |
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Measurement Mode | Q1 Scan/SIM |
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Q3 Scan/SIM |
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MRM |
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Precursor ion scan |
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Product ion scan |
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Neutral loss scan |
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Synchronized Survey Scan™*2) |
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Collision Cell | UFsweeper™*3) III | UFsweeper III | UFsweeper II | |
QP guard *4) |
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LCMS-8060RX | LCMS-8050RX | LCMS-8045RX |
- DUIS: The dual ion source continuously performs both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI).
- Synchronized Survey Scan: Synchronized Survey Scan (SSS) automatically performs a product ion scanning whenever a pre-set survey scan threshold is exceeded.
- UFsweeper: UFsweeper is a unique technology that delivers unparalleled efficiency and speed. UFsweeper accelerates ions out of the collision cell by forming a pseudo-potential surface.
- QP guard: Reduces contamination of the quadrupole rod by applying voltage to the multi-pole and preventing unwanted ions from entering the quadrupole rod.
LCMS-8060NX | LCMS-8060 | LCMS-8050 | LCMS-8045 | ||
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Features | On top of the architecture of the LCMS-8060, it adds flexibility in optimizing parameters to achieve unsurpassed sensitivity. New ion optic components all increase robustness without compromising on a high ion transmission rate. | A new vision in sensitivity. It is suitable for drug discovery, manufacturing, clinical research, food safety, environmental, or drugs-of-abuse analysis. | The first mass spectrometer to achieve a scan speed of 30,000 u/sec and 5 msec polarity switching time. It boasts the ideal balance of good data quality, high throughput and affordability for a wide range of challenging and routine applications. | Designed specially for robust data acquisition with best-in-class sensitivity. It withstands long periods of continuous operation in laboratories in demand of reliable data. | |
Sensitivity (S/N) | ![]() |
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Scan Speed | ![]() |
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Ionization Unit Compatibility | ESI | ||||
APCI |
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DUIS*1) |
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Heated-ESI |
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Heated-ESI with IonFocus |
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Micro-ESI |
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Probe-ESI |
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Measurement Mode | Q1 Scan/SIM |
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Q3 Scan/SIM |
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MRM |
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Precursor ion scan |
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Product ion scan |
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Neutral loss scan |
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Synchronized Survey Scan™*2) |
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Collision Cell | UFsweeper III*3) | UFsweeper III*3) | UFsweeper III*3) | UFsweeper II*3) | |
LCMS-8060NX | LCMS-8060 | LCMS-8050 | LCMS-8045 |
- DUIS: The dual ion source continuously performs both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI).
- Synchronized Survey Scan: Synchronized Survey Scan (SSS) automatically performs a product ion scanning whenever a pre-set survey scan threshold is exceeded.
- UFsweeper: UFsweeper is a unique technology that delivers unparalleled efficiency and speed. UFsweeper accelerates ions out of the collision cell by forming a pseudo-potential surface.
Application Specific LC-MS Systems Products
News / Events
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MSACL (Mass Spectrometry Applications to the Clinical Lab) 2025
September 23-25
Hotel Bonaventure Conference Center
Montreal, Canada
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ASMS (American Society for Mass Spectrometry) 2025
June 1-5
Baltimore Convention Center
Baltimore, MD -
PITTCON 2025
March 3-5
Boston Convention Center
Boston, MA -
Shimadzu Announces New LCMS RX Triple Quadrupole Mass Spectrometry Series
Shimadzu Scientific Instruments announces the new LCMS RX series of triple quadrupole mass spectrometry instruments. These advanced systems are supported by integrated hardware and software technologies to ensure reliable and robust results at lower operating costs, even under the most challenging and dynamic laboratory environments.
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Shimadzu Scientific Instruments Opens R&D Center
These forward-focused R&D centers will enable us to closely collaborate with customers and stakeholders to develop products that meet tomorrow’s analytical laboratory needs and swiftly deliver these solutions to the marketplace.
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Innovative Technology Developed by Shimadzu and Washington University is Expected to Improve Healthy Life Expectancy