LC/MS/MS Rapid Toxicology Screening System Ver.3

For LabSolutions™ LCMS

Library info for 231 compounds common in toxicology

This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization.
Rapid simultaneous analysis methods with analysis times under 15 mins are included for 231 compounds including drugs of abuse, psychoneurotic drugs and sedatives. The system also provides optimised conditions for synchronised survey scans used in screening measurements (conditions adopted for the product ion spectrum as a threshold value for the intensity in MRM).

Total solution including semi-quantitation

For each compound in the method, calibration curve information based on internal standards is available, so it is possible to obtain simple quantitative values after analysis. Using a pretreatment method based on the QuEChERS method^*, it is possible to comprehensively recover compounds from biological samples. Qualitative analysis using the spectral library can be carried out during the data processing stage. In other words, the system provides a total solution encompassing pretreatment, analysis and data processing.

Pretreatment using the Micro Volume QuEChERS Kit

>> *For details of the pretreatment method

Example of data analysis using LabSolutions Insight Library Screening:

Using LabSolutions Insight Library Screening, you can check all of the following:

(1) Quantitative results
(2) Library search results
(3) MS chromatogram
(4) MS/MS spectra
(5) Structural formula

List of registered compounds:

231 compounds including illegal drugs, sedatives, psychotropic drugs and medical drugs associated with many real-life cases.

IS Diazepam-D5（Positive）
IS_Phenobarbital-D5 (negative)
7-Aminoclonazepam
7-Aminoflunitrazepam
7-Aminonimetazepam
7-Aminonitrazepam
8-Hydroxyetizolam (M-III)
Acetaminophen
Aconitine
Alfa-methyltryptamine
Allylisopropylacetylurea
alpha-Hydroxyalprazolam
alpha-Hydroxymidazolam
alpha-Hydroxytriazolam
Alprazolam
Amitriptyline
Amlodipine
Amobarbital
Amoxapine
Amphetamine
Ampicillin
Aripiprazole
Atenolol
Atomoxetine
Atorvastatin
Atropine
Azelnidipine
Azilsartan
Barbital
Benzoyl ecgonine
Biperiden
Blonanserin
Brexpiprazole
Bromazepam
Bromocriptine
Bromovalerylurea
Bromperidol
Brotizolam
Bupivacaine
Caffeine
Candesartan
Carbamazepine
Carbazochrome
Carpipramine
Carvedilol
Chlordiazepoxide
Chlorpheniramine
Chlorpromazine

Chlorpromazine-M (bis-nor-)
Cibenzoline
Clobazam
Clocapramine
Clomipramine
Clonazepam
Clotiazepam
Cloxazolam
Clozapine
Cocaine
Codeine
Colchicine
DDVP
Delorazepam
DEP
Desipramine
Desmethylclotiazepam
Desmethyldiazepam
Dextromethorphan
Diazepam
Dibucaine
Diclofenac
Dihydrocodeine
Diltiazem
Diphenhydramine
Diprophyline
Diquat
Domperidone
Donepezil
Dosulepin
Droperidol
Duloxetine
Ecgonine methyl ester
Ephedrine
Escitalopram
Estazolam
Ethenzamide
Ethyl loflazepate
Etizolam
Famotidine
Fludiazepam
Flufenamic acid
Flunitrazepam
Fluphenazine
Flurazepam
Fluvoxamine
Furosemide

Gabapentin
Glibenclamide
Gliclazide
Glimepiride
Haloperidol
Haloxazolam
Hydroxymethylbrotizolam
Hydroxyzine
Ibuprofen
Imidapril
Imipramine
Irbesartan
Isopropylantipyrine
Ketamine
Ketoprofen
Lamotrigine
Levetiracetam
Levomepromazine
Lidocaine
Lorazepam
Lormetazepam
Losartan
Loxoprofen
Malathion
Maprotiline
MDA
MDMA
Medazepam
Mefenamic acid
Memantine
Mepivacaine
Mequitazine
Metformin
Methamphetamine
Methomyl
Methylephedrine
Methylphenidate
Mexazolam
Mexiletine
Mianserin
Midazolam
Milnacipran
Mirtazapine
Morphine
Mosapramine
Naftopidil
N-Desmethyl clobazam

N-Desmethyl zopiclone
N-Desmethylmirtazapine
Nemonapride
Nicardipine
Nicotine
Nicotine-M
Nifedipine
Nimetazepam
Nitrazepam
Norephedrine
Nortriptyline
Noscapine
Olanzapine
Olmesartan
Oxazepam
Oxypertine
Paliperidone
Papaverine
Paroxetine
Pemoline
Pentazocine
Pentobarbital
Perospirone
Perphenazine
Phenobarbital
Phenytoin
Pimozide
Pioglitazone
Pipamperone
Piroxicam
Pitavastatin
Pranlukast
Primidone
Procaine
Prochlorperazine
Promethazine
Propericiazine
Propofol
Propranolol
Quazepam
Quetiapine
Risperidone
Ropivacaine
Rosuvastatin
Salicylamide
Salicylic acid

Secobarbital
Sertraline
Setiptiline
Sildenafil
Silodosin
Sitagliptin
Solifenacin
Spiperone
Spironolactone
Sulfamethoxazole
Sulpiride
Sultopride
Suvorexant
Tadalafil
Tandospirone
Telmisartan
Temazepam
Tetracaine
THC
THC-COOH
Thiamylal
Timiperone
Tofisopam
Topiramate
Tramadol
Trandolapril
Trazodone
Triazolam
Trihexyphenidyl
Trimethoprim
Trimipramine
Urapidil
Valproic Acid
Valsartan
Vardenafil
Venlafaxine
Verapamil
Warfarin
Zalepron
Zolpidem
Zolpidem _M-1
Zonisamide
Zopiclone
Zopiclone-N-oxide
Zotepine

Remarks and Precautions

LabSolutions LCMS Ver. 5.109 or later and LabSolutions Insight Ver. 3.8SP1 or later are required.
Depending on the condition and specifics of the equipment used, differences in quantitative values may occur. For accurate quantitative values, please use a calibration curve method with appropriate standard samples. In addition, scores obtained from searching in the library show the similarity of spectra and form one basis for the identification of compounds, but for more accurate compound identification it is more effective to combine multifaceted information such as retention times and sample information.

LabSolutions is a trademark of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.

For Research Use Only. Not for use in diagnostic procedures.

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