Nexera Prep SFC System

Semi-Preparative Supercritical Fluid Chromatography System

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Unparalleled Preparative Performance, Unparalleled SFC Flexibility

Semi-Preparative Supercritical Fluid Chromatography System

The Nexera Prep SFC System

 

The Nexera™ Prep SFC is a preparative supercritical fluid chromatography (SFC) system that offers both the high basic performance developed for the Nexera Analytical SFC model and the original state-of-the-art preparative SFC technologies. It resolves a number of issues in preparative tasks, reducing labor and improving efficiency while fitting into pre-existing workflows. Not only does the Nexera Prep SFC achieve superior recovery rates for purification, it also provides flexible system configurations in a compact design, requiring low installation space and allowing you to maximize lab resources.

Designed in collaboration with the Enabling Technologies Consortium (ETC)
Addresses historical issues in SFC prep purification
Creates new benchmarks in fraction recovery and low carryover
Minimizes bench footprint in a truly compact design

Three Workflow Goals – Three Configurations

Stacked Fraction System: Prep SFC w/FRS-40

For the repetitive purification of a small number of fractions (up to 10), but of a large volume for each fraction (1L bottles default, option to use larger bottles).
Perfect for both chiral and achiral separations
LotusStream™ Gas-Liquid Separator on each collection bottle
Sample injection volumes up to 20 mL; flow rates from 10 to 150 mL/min.
Supports stacked injections

Prep Purification SFC w/FRS-40 – Stacked Fraction System

 

Multi-Fraction System: Prep SFC w/FRC-40 SF

For the purification of a large number of fractions, but of a smaller volume for each fraction (from 216 eighteen mm test tubes up to 12 one liter bottles).
Perfect for both chiral and achiral separations
LotusStream™ Gas-Liquid Separator integral to the collection head
Sample injection volumes up to 2 mL; flow rates from 10 to 150 mL/min.

Prep Purification SFC w/FRS-40 – Stacked Fraction System

 

Large-Scale Multi-Fraction System: Prep SFC with LH-40 SF

For purification of a large number of fractions with larger injection volume up to 20 mL, flow rates from 10 to 150 mL/min
LH-40 SF offers the functionality of both, an injector and a fraction collector
Perfect for both chiral and achiral separations
LotusStream™ Gas-Liquid Separator integral to collection head
Supports stacked injection with addition of FRC-40 SF fraction collector

Prep Purification SFC w/FRS-40 – Stacked Fraction System

 

Features

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Latest Webinar

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Videos

  • Nexera UC+FRC-40SF_2ｍLvial (side)

    • Liquid Chromatography

    Direct fractionation into vials

  • Nexera UC+FRC-40SF_96well (up)

    • Liquid Chromatography

    Direct fractionation into 96-well plate

  • Harnessing the Power of Collaboration: Shimadzu’s SFC Journey

    Join us as we discuss the collaborative process that led from the introduction of Shimadzu’s Nexera UC analytical SFC systems to the Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC systems. We will explore the uses of SFC and see how the Shimadzu lineup has been shaped to meet the needs of Pharma SFC users through their direct input into instrument and software design and development.

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