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Ultra High Performance Liquid Chromatograph

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Modular UHPLC/HPLC Systems - Nexera Series
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Compact, rugged, reliable.
Nexera 40 Series UHPLC/HPLC Systems

Accuracy and repeatability with minimal downtime and maintenance

The Nexera 40 Series UHPLC/HPLC Systems are designed for high-throughput sample processing with exceptional accuracy and minimal maintenance. These rugged systems are the smallest in the industry, providing a reduced footprint without sacrificing autosampler capacity. Built on Shimadzu’s legacy of LC reliability, the system also offers optics temperature control for stable results and flexibility with various detectors and configurations. Ideal as a front-end system for mass spectrometry applications, the Nexera 40 Series can be customized for the users specific needs.

To further enhance accuracy, the Nexera 40 Series features the Intelligent Peak Deconvolution Analysis (i-PDeA) function. This groundbreaking technology, unique to Shimadzu, ensures accurate quantitation even for co-eluted compounds by utilizing spectral differences between each compound, setting a new standard in peak analysis.

Key Features

Key features of the Nexera HPLC and UHPLC Systems
  • Remarkably small footprint
  • High capacity sample handling with optional plate changer
  • Ultra-fast injection cycles (7 sec) with lowest carryover
  • Smart Flow control during start-up and shutdown
  • Auto-diagnosis and auto-recovery from flow anomalies
  • Remote maintenance and laboratory management
  • LabSolutions software for unified laboratory management
  • Data analysis with Intelligent Peak Deconvolution Analysis (i-PDeA)

Quick Specs


Maximum Operating Pressure		 40D: 44 MPa
XR: 70 MPa
XS: 105 MPa
X3: 130 MPa

Solvent Delivery		 Parallel-type double plunger (approx. 10 μL/1 stroke)

Injection volume		 SIL-40/C: 0.01 to 100 µL
SIL-40C XR/XS/X3: 0.01 to 50 µL
0.01 to 2000 μL (optional for all models)

Sample Capacity		 From 3x MTP's (96 well and 384 well) to 36 ten mL vials. Several vial sizes in between.

Cooled Plate Changer		 1 Plate Changer: From 16x MTP's (96 well and 384 well) to 9x ten mL vial plates. Several vial sizes in between.
3 Plate Changers: From 44x MTP's (96 well and 384 well) to 23x ten mL vial plates. Several vial sizes in between.

Carryover		 SIL-40/C: ≤0.0025% (without rinse), ≤0.0005% (with rinse, typically)
SIL-40C XR/XS/X3: ≤0.0015% (without rinse), ≤0.0003% (with rinse, typically)
(under specified conditions)

Column Oven		 CTO-40C: Forced air circulation, 100ºC, fit 6x 250 mm column or 3x 300 mm columns
CTO-40S: Forced air circulation, 85ºC, fit 6x 100 mm column or 3x 300 mm columns

Detectors		 UV/Vis, PDA, Fluorescence, Refractive Index, Conductivity, ELSD, MS (Single/Triple Quad, TOF)

 

Low-pulsation pumps provide steady flow for accurate results

  • Reliable pump flow for high reproducibility

    Analysts rely on Nexera HPLC and UHPLC pumps for their high flowrate accuracy, gradient repeatability and consistent peak retention times. These pumps feature low-pulsation and dual piston design for sharp and narrow peaks with high reproducibility.

    Nexera HPLC and UHPLC pumps are available in four different pressure tiers, so you can customize your system to fit various applications.

    Combined with LabSolutions, they are capable to perform auto-diagnostic and auto-recovery functions, which help to avoid mid-analysis failure caused by flow anomalies, reducing sample waste and minimizing downtime

  • Low-pulsation hplc pumps provide steady flow for accurate results
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Ultra-fast, precise autosamplers for enhanced efficiency

  • Ultra-fast, precise hplc autosamplers for enhanced efficiency

  • Reduce carryover and improve sensitivity with automated features

    Nexera HPLC and UHPLC autosamplers deliver ultra-low carryover for accurate results and fewer reruns, with ultra-fast injection speeds every 6.7 seconds.

    Offering high precision, excellent linearity and large sample capacity, these autosamplers enhance efficiency with automated pre-treatment functions like co-injection, dilution, reagent addition and overlap injections

    The inert configuration is ideal for biomolecules and sticky molecules, reducing carryover and improving sensitivity for reliable performance in demanding applications.

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Enhance analytical performance with Shimadzu front-end LC systems

  • Optimize mass spectrometry with Shimadzu’s leading liquid chromatographs

    Shimadzu liquid chromatographs are the preferred choice for LC-MS front ends around the world, known for their precision, reliability and compatibility. These front-end systems maximize the performance of mass spectrometers by delivering highly accurate and reproducible results.

    With flexible configurations, users can seamlessly integrate Shimadzu LCs with various mass spec platforms, ensuring optimal performance regardless of the system. In addition to superior chromatography, Shimadzu’s robust design reduces downtime, making it a trusted solution for labs aiming for efficient, high-throughput analysis.

  • Enhance analytical performance with Shimadzu front-end LC systems
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Featured Content

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Videos

  • How To Manually Prime a Shimadzu LC 40 Pump

    • Liquid Chromatography

    This video demonstrates the proper procedure to manually prime the pump on a Shimadzu LC 40 instrument.

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    • Liquid Chromatography

    - Experience New Benchmarks - The Nexera series is a family of HPLC systems that marries AI and IoT enhancements to set new industry

  • Nexera series Concept Video

    • Liquid Chromatography

  • How To Clean or Replace the Check Valves on a Shimadzu LC-40 Series Nexera Pump

    • Liquid Chromatography

    In this video, you will learn how to safely clean or replace the check valves on a Shimadzu LC-40 Series Nexera pump.

  • How To Replace the Plunger Seal on a Shimadzu LC-40 Series Nexera Pump

    • HPLC/UHPLC/SFC Systems

    This video shows the proper procedure to safely remove and replace the plunger seal on the Shimadzu LC-40 Series Nexera pump.

  • Enhancing Lab Performance with Nexera™ Auto-Recovery & Auto-Diagnostic Features

    • Liquid Chromatography

    Regular maintenance is crucial to keep your HPLC and UHPLC instruments running at peak performance and getting accurate results. Shimadzu's Nexera UHPLC Series features auto-diagnostic and auto-recovery features that automatically detect abnormal pressure fluctuations, preventing data loss and wasted samples.

  • Ensuring Data Accuracy & Reliability with Smart Flow Control

    • Liquid Chromatography
    • LC Columns

    UHPLC and HPLC analysis require careful management of flow rate to reduce maintenance costs and protect valuable columns. Shimadzu’s Smart Flow Control helps protect expensive analytical columns and ensures you get accurate, reliable results you can trust. This intelligent start-up feature slowly increases the flow rate to avoid damaging critical equipment.

  • Real-Time Mobile Phase Monitoring — Nexera™ UHPLC Series

    • Liquid Chromatography

    Making sure you have sufficient mobile phase in your HPLC or UHPLC systems is critical to keeping your lab running smoothly. Shimadzu’s Nexera UHPLC Series enables real-time monitoring of mobile phase levels to ensure maximum equipment uptime.

  • One minute in Shimadzu

    What can we do in one minute? You may feel like one minute is too short for anything to really happen. In this short video, we will introduce how Shimadzu's analytical instruments can perform high-speed analysis and bring value to our customers in one minute.

  • How to Replace Flow Cell Lenses and Gaskets on the Shimadzu SPD-M40 and SPD-40 Detectors

    • Liquid Chromatography
    • Nexera HPLC/UHPLC Detectors

    In this video, an LC Product Specialist at Shimadzu Scientific Instruments demonstrates how to replace lenses and gaskets as part of the preventative maintenance routine for the SPD-M40 Photodiode Array Detector and SPD-40 UV/VIS Detector Flow Cells.

    This video overviews the importance of maintenance, outlines the necessary tools, and provides step-by-step instructions cover the removal of the flow cell, extraction of the old lenses and gaskets, cleaning of the flow cell interior and reassembling/reattaching the flow cell

  • Shimadzu Scientific Instruments Collaboration with Dawen Kou of Genentech

    Dawen Kou of Genentech talks about his experiences of working with Shimadzu over the last few years and the excitement of growing the collaboration in the future.

  • How To: Replace the UV-Vis lamp in a SPD-40 and SPD-40V UV/Vis Detector.

    • Liquid Chromatography

    In this instructional video, an LC Product Specialist at Shimadzu Scientific Instruments explains the process of replacing deuterium and tungsten lamps as part of the preventative maintenance routine for the SPD-40 and SPD-40V UV/Vis Detectors.

    This video overviews the importance of lamp maintenance and provides step-by-step instructions and the necessary tools required for the task and provides safety tips to prevent injuries during the procedure. Viewers learn how to secure the lamps properly, reassemble the detector, and reset the lamp operating time

  • How to Replace Deuterium and Tungsten Lamps for the SPD-M40 Photo Diode Array Detectors

    • Nexera HPLC/UHPLC Detectors

    This video overviews the importance of lamp maintenance and provides step-by-step instructions and the necessary tools required for the task and provides safety tips to prevent injuries during the procedure. Viewers learn how to secure the lamps properly, reassemble the detector, calibrate the detector and reset the lamp operating time.

  • How to Replace Flow Cell Lenses and Gaskets on your HPLC

    In this video, an LC Product Specialist at Shimadzu Scientific Instruments demonstrates how to replace lenses and gaskets as part of the preventative maintenance routine for the SPD-M40 Photodiode Array Detector and SPD-40 UV/VIS Detector Flow Cells.

    This video overviews the importance of maintenance, outlines the necessary tools, and provides step-by-step instructions cover the removal of the flow cell, extraction of the old lenses and gaskets, cleaning of the flow cell interior and reassembling/reattaching the flow cell.

  • Features of LabSolutions MD: HPLC Method Development Support Software

    LabSolutions MD uses an “Analytical Quality by Design” (AQbD) approach for achieving efficient method development by designing analytical methods based on ICH guidances, science and statistical evaluation. All workflow steps can be completed using LabSolutions MD. By streamlining the method development workflow into three phases: screening, optimization, and robustness, the user receives the best and the most robust method at the end of the process.

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