Small Molecule Analysis Compendium

Starting in basic target discovery, the need for investigatory pharmaceutical research is present at every stage in the development and launch of a therapeutic product. Even after release there can be a need to investigate unexpected drug outcomes or issues with process manufacturing. Often the degradants, metabolites, or interactions with endogenous compounds need to be elucidated in the process of drug development which may require a multitude of techniques from matrix-assisted laser desorption ionization (MALDI) mass spectrometry to crystalline transition thermal analysis.

With Shimadzu’s full line of analytical instrument solutions, we offer tools to meet the needs of your tasks characterizing novel small molecules. For basic metabolomics research, advanced method development, or process impurity identification, our flexible and robust instrument solutions are the ideal platform for your small molecule analysis.

• Analysis of Minor Components in Water Using the IRSpirit
• Pharmaceutical Excipient Identification Test Using IR Pilot™
• Contaminant Analysis of Pharmaceuticals (Tablets) Using AIRsight Infrared/Raman Microscope

• Comparison of Sensitivity for Sulfur Compound Species by Nexis™ SCD-2030: Equimolar Sensitivity Measurement

• Comprehensive Detection and Structural Elucidation of Synthetic Cathinones Using GC-MS/MS
• Profiling Trace Volatile Compounds in Blood by Gas Chromatograph Mass Spectrometry with Dynamic Headspace Extraction
• Analysis of Glycolysis Metabolites in Human Embryonic Stem Cells using GC-MS/MS

• Improved Analytical Workflow for Phospholipids by Nexera-e and Co-Sense for Impurities
• Separation of Lipids Using the Nexera UC Supercritical Fluid Chromatograph
• Analysis of Ions in Drugs (Part 5) Analysis of Organic Acid Counterions by Ion Exclusion Chromatography
• Simultaneous Analysis of Carboxylic Anhydrides and Hydrolysates Using Supercritical Fluid Chromatography
• Determination of Ticagrelor and its related impurities content from oral tablets as per proposed IP monograph UHPLC method

• Simplified approach for structural elucidation and quantitation for pharmaceutical API and related impurities
• Structural Analysis of Impurities in Pharmaceuticals Using Trap-Free 2D HPLC and the LCMSTM-9030
• Lipid Mediator Profiling of Human Serum Using the Triple Quadrupole LC/MS/MS
• Development of bioanalytical method for determination of intact human insulin from plasma using LC/MS/MS
• LC/MS/MS Method Package for Steroid Hormones
• Analysis of Impurities in Montelukast Using Single Quadrupole Mass Spectrometer

• MS Imaging of Low Molecular Weight Metabolites Using a Sublimation/Recrystallization Method with 9-Aminoacridine (9AA)
• Rapid Measurement of Low-molecular Compounds Using a Benchtop MALDI-TOF Mass Spectrometer
• Characterisation of a PEG Conjugated Medicine; Polymer Analysis Using the MALDI-8020 Benchtop Linear MALDI-TOF Mass Spectrometer

• Polymorphism of Drugs
• Reaction Rate Analysis by Thermal Analysis