Preparative Liquid Chromatography

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When conducting preparative chromatography for your drug candidate, its imperative to have an LC system that provides exceptional purity results, operates efficiently, and has a user-friendly interface. Our prep LC systems offer a wide array of solutions from our highly flexible fraction collectors, our liquid handlers that reduce workload and improve throughput, and our software that allows you to get your runs going all within a matter of a few clicks.

Fraction purity checks (LH-40)

A fraction purity check can easily be performed with a single system. Purity checks can be performed without changing the fraction recovery container, so the workload is reduced and throughput is improved.

Sample rescue function prevents the loss of precious samples (LH-40, FRC-40)

Even if a problem occurs during preparative work, the sample remaining in the system can be recovered. By following the rescue instructions, the precious sample is recovered into the specified container rather than being discarded. Additionally, by using the optional waste collector, samples that cannot be recovered due to fractionation mistakes can be retained.

FRC-40, the highly flexible fraction collector

$FRC-40, the highly flexible fraction collector$

Accommodates up to 3,240 test tubes
Large-scale fractions of the order of one liter can be accommodated, in addition to 96 well MTPs and a variety of test tubes. Up to six units can be connected, allowing users to customize the unit to their capacity needs.

A variety of containers can be selected
The system is compatible with various capacity racks to suit the volume needs of almost any workflow, reducing the work involved in switching containers.

Space-saving design
With its small installation footprint, up to nine MTP, standard vial racks, or test tube racks can be selected, contributing to the effective use of laboratory space.

Sample racks

A variety of containers can be placed including MTPs, vials, and various types of test tubes. Six colors are available, so a separate color can be apportioned to each user in order to avoid confusing samples.
Multi fraction collector kit

Up to six FRC-40 fraction collectors can be connected, making it easy to increase the number of fractions.

$nexera prep lc fraction collector kit$

The LH-40 liquid handler: a combination of autosampler and fraction collector

Provides both a sample injection function and a fraction collection function
A single unit can perform everything from sample injection to fraction recovery.

Suppresses contamination
A proprietary injection method minimizes carryover, significantly limiting contamination to subsequent samples. (When a 4000 mg/L caffeine sample is injected, the carryover is 0.004 % or less.)

Capable of injection from a variety of containers
With its long needle stroke, the system is compatible with containers of varying depths, including microtiter plates (MTP), vials, test tubes, and sample bottles.

Featured Applications

High Throughput Preparative LC with Auto Switching Dilution Injection Function

Preparative LC is a widely used purification technique. High throughput purification is required in various industries. However, large volume injection which is required to achieve high throughput purification,causespeak broadening. This article introduces a large amount of injection and a high throughput preparative LC using dilution injection.

Preparative Purification of Ibuprofen and Related Substances by Nexera UFPLC

Preparative LC is a widely used purification technique. High throughput purification is required in various industries. However, large volume injection which is required to achieve high throughput purification,causespeak broadening. This article introduces a large amount of injection and a high throughput preparative LC using dilution injection. This article introduced an example of preparative purification of a mixed sample of the pharmaceutical ibuprofen and its analogues by using UFPLC. By concentrating, purifying, and recovering the fractionation with UFPLC, the drying time of the highly concentrated fraction of ibuprofen was reduced to about half compared with standard preparative LC. Automating the concentration and purification processes online, enables labor and time savings in the preparative purification process. Moreover, the Nexera UFPLC is extremely flexible and can be used for both standard preparative LC and UFPLC.

Workflow Enhancement for Purification of New Synthetic Compounds in Drug Discovery Process

This article introduces workflow enhancement for drug discovery from screening to purification. Open Solution software and ASAPrep algorithm provide easy and labor-saving operations to check screening results and preparative method development. Automatic workflow for purification is expected to increase productivity and reduce labor costs.