Vol.2, Issue2-April 2014 CONTENT

Dr. Paul Wynne from Shimadzu Australia spoke with Dr. Michelle McIntosh, Senior Lecturer in the Faculty of Pharmacy and Pharmaceutical Sciences at the Monash Institute of Pharmaceutical Science (MIPS) in Melbourne, Australia, about her work in drug metabolism and disposition.

Dr. Michelle McIntosh of the Monash Institute of Pharmaceutical Sciences and her team describe their efforts to prevent women in developing countries from Postpartum haemorrhage (PPH), the fatal loss of blood after childbirth.

The visualization and quantitative analysis of native drug distribution in a pre-clinical or clinical setting are desirable for evaluating drug effects and optimizing drug design. Here, using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) with enhanced resolution and sensitivity, we compared the distribution of a paclitaxel (PTX)-incorporating micelle (NK105) with that of PTX alone after injection into tumor-bearing mice.

These are articles selected by Shimadzu. They derive from application notes relating to Clinical Research and feature a variety of instruments we produce. Cutting-edge technologies are also included. Please obtain the articles of your interest via the links on the titles.

[New Technology]
Paradigm Shift in Cancer Diagnosis: Basics and Algorithm (Page 74)

PESI-MS is an innovative new technique to diagnose diseases, particularly cancer, based on single quadrupole LC-MS.This article overviews the gadgetry, elementary techniques and resources.

[Latest News]
Shimadzu Opens New Quality Center (Page 75)

In response to a growing need for analytical measurement in healthcare applications, Shimadzu Corporation, Japan, has registered several of the company’s HPLC and LC-MS as Class I medical devices with the Food and Drug Administration.

This training was conducted under the Shimadzu-A.Nakamoto Scholarship program as part of activities to assist human resource development that started after Shimadzu's President, Akira Nakamoto, received an honorary doctorate from VNU.