Drug Discovery

Biomarker Discovery, Screening & Drug Synthesis

Shimadzu provides both analytical and medical instrument technologies for drug discovery research. The goal of drug discovery is to qualitatively investigate a large number of compounds, narrow the selection through more targeted synthesis and then screen, optimize and select the seed compounds to deliver potentially viable therapeutic candidates. Shimadzu is leveraging and fusing its core analytical and medical technologies to deliver powerful new drug discovery platforms. A specific focus is to develop advanced technologies in the area of molecular imaging.

  • Solutions
  • System Lineup

Biomarker Discovery System

Biomarker Discovery System The AXIMA series provides linear, linear/reflectron and TOF/TOF MALDI mass spectrometers for drug discovery applications.


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Ultra Fast MW Confirmation LC/MS System for Synthetic Compounds

Once a target compound is synthesized, it needs to be confirmed as quickly as possible for downstream processes. An Ultra Fast MW Confirmation system consisting of Prominence UFLC and an LCMS-2020 mass spectrometer is a powerful choice for such analysis. LCMS-2020 captures all the narrow peaks separated by Prominence UFLC in shorter run times. LCMSsolution software also supports easier operation and integrated workflows.

Ultra Fast MW Confirmation LC/MS System for Synthetic Compounds


Preparative Isolation LC System with MS for Chemical Synthesis

High purity and high efficiency are important in preparative isolation process, particularly for such next steps as efficacy and pharmacokinetic studies. Shimadzu LC modular systems are flexible and allow configurations required for preparative scale chromatography. PsiPortTM software and the LCMS-2020 mass spectrometer ensure qualitative and quantitative analyses of target fractions. A 'one click' approach to sample analysis allows to use pre-configured methods and customized reporting templates.

Metabolomics Research


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Data Systems Data Systems and Data Management Tools
In the pharmaceutical industry, compliance to regulations and guidelines, such as CSV and PIC/S GMP and U.S. FDA 21 CFR Part 11, and the proper, efficient management of instrumentation and analytical data is required. Shimadzu's LabSolutions network-compatible analysis data system provides a fast and efficient management of instruments. Review our lineup of Data Management Software tools: LabSolutions LC/GC, LabSolutions DB, LabSolutions CS, LabSolutions GPC, LabSolutions IR, LabSolutions RF, Class-Agent and C-R8A Integrator.
Multi-vender software support Multi-vendor software support
Shimadzu has worked closely with other chromatography vendors to provide software drivers enabling other vendor's software to control our instrumentation. Review our lineup of vendor software drivers: LC driver for Waters Empower 3, GC driver for Waters Empower 3, i-Series LC driver for Waters Empower 3, LC drivers for Agilent's OpenLAB CDS EZChrom, GC driver for Agilent's OpenLAB CDS EZChrom, LC driver for Thermo Scientific Chromeleon 6.8, SPD-M30A Photodiode-array LC detector driver for Thermo Scientific Chromeleon 7.2.
LC/HPLC Liquid Chromatography
For over 40 years Shimadzu has been recognized as a leader in innovative and robust Liquid Chromatography instrumentation. Liquid chromatography has become an integral analytical tool for researchers and analysts across the entire workflow of Pharmaceutical and Biopharmaceutical analysis from Drug Discovery through Clinical Trials and into production and Quality Assurance. Whether your requirements are for a stand-a-lone HPLC/UHPLC or as a front-end to Mass Spectrometry Shimadzu's line of liquid chromatography products will meet or extend your application needs. Review our comprehensive lineup of instruments: Nexera X2 UHPLC, Nexera SR UHPLC, Nexera MP Front End UHPLC, Nexera UC SFE-SFC, Nexera-e 2D-LC, Nexera-i Integrated UHPLC, Nexera HPLC/UHPLC Method Scouting, Prominence HPLC, Prominence UFLC, Prominence-I Integrated HPLC, Prominence nano LC, Prep LC, Crude2Pure Auto Purification/Powderization HPLC system, Co-Sense 2D-LC system for Bioanalysis.
LC-MS LCMS
With the fastest multiple reaction monitoring (MRM) transition times available today, high-speed multi-analyte detection with 500 MRM transitions in one second, and unsurpassed polarity switching speed, the LCMS-8060, LCMS-8050, LCMS-8040 and LCMS-8030 triple quadrupole LC/MS/MS systems delivers speed beyond compare. Combining these advanced mass spectrometry technologies with Shimadzu's world-leading Nexera UHPLC performance creates a unique system approach to ultra fast mass spectrometry detection.
MALDI-MS MALDI-MS
MALDI-MS systems provide reliable mass information with higher sensitivity and throughput for the molecular identification and characterization of biomolecules. In particular, the LCMS-IT-TOF MS system shows superior performance without compromise on high resolution and accurate structural analyses. Review our comprehensive line of instruments: MALDI-7090, AXIMA Assurance, AXIMA Confidence, AXIMA Performance, MegaTOF Megadalton MALDI, Glycan Analyzer, Micro-organism Identification, AXIMA-iD Plus MALDI-TOF Platform.
Dried Plasma Spots Dried Plasma Spots
NoviplexTM cards are a simple, powerful tool used to collect a volumetric sample of plasma (2.5 µL) from a non-volumetric application of whole blood in just minutes.
Automated Protein Seperation Automated Protein Seperation
Perfinity technology, through automation and patented immobilized enzyme reactor columns, accelerates protein sample preparation workflows and provides reproducibility to proteolysis which cannot be obtained through traditional methods.
Prep-scale liquid chromatography Prep-scale liquid chromatography
Shimadzu has installed more than 2000 preparative HPLC systems throughout the world, and remains committed to improving the purity and speed of separation and making this technique more cost effective. Using our broad experience and technologies at various scales and in diverse fields, we have significantly enhanced the performance that can be obtained from preparative HPLC.
Nexera UC Nexera UC SFE-SFC
Supercritical fluid enables highly efficient sample extraction and chromatographic analysis. The Nexera UC uniquely combines supercritical fluid extraction and supercritical fluid chromatography to provide the industries’ first online Unified Chromatography system. Various configurations are available including on-line SFE-SFC-MS, SFC-MS, SFC Chiral Screening System, and SFC-UV.
LC-MS Nexera Comprehensive 2D-LC
Nexera-e enables the separation of even the most complex mixtures, providing a new level of knowledge and understanding of sample analytes. This is especially beneficial for the identification and quantitation of analytes in pharmaceutical impurities, peptides, lipids, and proteolytic digests.
LC-MS Nano-scale Liquid Chromatography
The Prominence nano is a nanoflow LC system consisting of Prominence Series units, including a flow line switching valve for nano-level flow control, and a solvent delivery unit that demonstrates excellent flow rate accuracy even at nano-level flows. Two system configurations are available, including a basic 1-dimensional system that adopts the trap injection system and a 2-dimensional system in which reversed-phase separation is automatically conducted following the first stage cation-exchange separation.
Gas Chromatography Mass Spetrometry Gas Chromatography Mass Spectrometry
For over 30 years Shimadzu has been a leader in design innovations, such as our front access ion source, high efficiency ion optics, 20,000 µ/second scan speed, and post-quadrupole focusing lenses. Shimadzu is a market leader in system ruggedness combined with exceptional performance, simplified operation, and maintenance. Review our comprehensive lineup of instruments: the GCMS-TQ8040 with Smart MRM, GCMS-QP2010 Ultra, and the GCMS-QP2010 SE.
Crude2Pure Crude2Pure
Crude2Pure systems provide purification/powderization after retention and concentration of fractions of target compounds obtained by a preparative LC system.
Edman Chemistry Protein Sequencer Edman Chemistry Protein Sequencer
Protein sequencing via automated Edman degradation chemistry remains a simple and robust solution for many labs, delivering unambiguous data that is much less complex than the data obtained through mass spectrometry-based techniques.
Micro-volume UV-Visible Spectrophotometers Micro-volume UV-Visible Spectrophotometers
The Shimadzu BioSpec-nano is a low-maintenance micro-volume spectrophotometer designed for the modern life science laboratory. It offers superior detection limits compared to comparable competitive systems, making it the perfect instrument for quantitation of DNA, RNA, protein analysis, and photometric measurements. Quantitation can be rapidly and simply measured required volumes of only 1µL. And, with dedicated functions, such as automated sample mounting and wiping, the BioSpec-nano offers a rapid 3-second analysis time and a 10-second cycle time between samples.
UV-Visible Spectrophotometers UV-Visible Spectrophotometers
Shimadzu has been developing UV-Vis spectrophotometers for 60 years, and continues to manufacture instruments that meet scientists' needs for ruggedness, ease of use, validation and applications. Our current lineup features the general, all-purpose UV-1800 with best-in-class resolution (1nm) and built-in biological software, introductory research-grade UV-2600, with an extended range to 1400nm, and the double monochromator UV-2700, which is capable of high Abs measurements. These compact systems are equipped with proprietary low-ray-ligh gratings, offer USB connectivity, and come with the full-featured UVProbe software.
Particle Analyzers Particle Analyzers
From dense to super-fine particles, Shimadzu has the high-performance Particle Size Analyzer for applications in pharmaceuticals, metals, minerals, cosmetics, food, civil engineering, the environment and more.
X-ray X-Ray Instruments
Energy Dispersive X-ray (EDX) fluorescence spectrometry is used to perform qualitative and quantitative analysis of samples by measuring re-emitted characteristic X-rays from elements. The ideal tool for non-destructive applications, EDX allows measurement of a wide variety of sample types, such as solids, powders, and thin films, in many different applications areas, including electronics, chemicals, and foods.
Fluorescnce Fluorescence
Fluorescence is typically 100 to 1000 times more sensitive than traditional absorption techniques. Providing enhanced sensitivity and dynamic range the RF-6000 Spectrofluorometerenables a wide-range of Luminescence measurement techniques including Fluorescence, Phosphorescence, Bioluminescence, Chemiluminescence, and Electro-Luminescence. Application areas include Pharmaceuticals, Life Science research, Chemicals, Environmental, Foods, and Electrical/Electronics.
Balances Balances
Shimadzu has introduced user-friendly instruments and features to the market, such as: the temperature-based fully-automatic calibration in 1985, the first one-piece force cell (OPF, later renamed UniBloc) in 1989, the high-sensitivity AEM-5200 Micro Balance in 1993, and the unique Windows® Direct feature perfectly suited for the computerized laboratory of the 21st Century. Moving forward, Shimadzu is committed to providing innovative products for the analytical marketplace. Learn more now.